Structure Elucidation

We develop novel small-scale small-molecule synthetic reagents, primary standards and chemical markers for pharmaceutical, biotechnology, clinical and contract research organizations (CROs). These compounds can be with or without isotopic labeling.

Structural determination of existing and new chemical entities (NCEs) are performed and confirmed by using the four (4) principal spectroscopic techniques, namely Mass Spectrometry (MS), Nuclear Magnetic Resonance, Infrared (IR) and Ultraviolet/Visible (UV/VIS).

MS, using different ionization modes (EI, CI, ESI, APCI, etc.), is used to produce characteristic molecular fragmentation patterns that are ultimately used to determine molecular weight information.

NMR, using multi-nuclear probes and varying decoupling techniques, is used for the determination of structural components of molecules, and uniquely useful to determine stereoregularity.

IR is used to identify functional groups, isomerism and crystallinity.

UV is used as an ancillary technique to confirm MS, NMR and IR.

LC, GC and TLC separation techniques are used to confirm peak/product uniformity and to isolate/identify any impurities.

Our final product contains all spectroscopic and chromatographic documentation summarized in a Certificate of Analysis (CoA) as well as Material Safety Data (MSD) information.

A non-proprietary example of a typical Certificate of Analysis, including all supporting documentation containing spectra and corresponding structure, may be seen by clicking on the link in the Certificate of Analysis and then the corresponding individual spectroscopic subsection.

The example CoA is based on 7-Hydroxy Propranolol, and is only 1 metabolite of Propranolol.